Our pipeline

Current products under development

Products

Discovery

Preclinical

Clinical

PTI5803

reformulated existing entity

Orphan pediatric syndrome

Other orphan epilepsies

New leads

Panx1 blockers

Focal epilepsy

Multiple sclerosis

Oter CNS diseases

Targeting Pannexins-1 to prevent seizures

Pannexin-1 contributes to seizure generation

In human epileptic brain tissue
In a representative mouse model of chronic Epilepsy

Pannexin-1 is related to the epileptic condition

Poorly expressed in healthy tissue
Highly expressed in pathological tissue

Pannexin-1 are activated during seizure process

Increase of permeability
Flux of larger molecules such as ATP

Pannexin-1 blocker drug is a specific therapy

State-dependent activity
Prevents seizures
Does not affect basal brain activity

Ref: Dossi et al., 2018 – Science Transl Med ; Michalski et al., 2020 – Elife ; Dossi et al., 2021 – Purinergic Signal