Our pipeline

Current products under development

Products

Discovery

Preclinical

Clinical

PTI5803
reformulated existing entity
Orphan pediatric epilepsy (ODD ongoing)
Other orphan epilepsies
New leads
Panx1 blockers
Focal epilepsy
Multiple sclerosis
Other neurological diseases

Targeting Pannexins-1 to prevent seizures

Pannexin-1 contributes to seizure generation

  • In human epileptic brain tissue
  • In a representative mouse model of chronic Epilepsy

Pannexin-1 is related to the epileptic condition

  • Poorly expressed in healthy tissue
  • Highly expressed in pathological tissue

Pannexin-1 are activated during seizure process

  • Increase of permeability
  • Flux of larger molecules such as ATP

Pannexin-1 blocker drug is a specific therapy

  • State-dependent activity
  • Prevents seizures
  • Does not affect basal brain activity

Ref: Dossi et al., 2018 – Science Transl Med ; Michalski et al., 2020 – Elife ; Dossi et al., 2021 – Purinergic Signal